| Autor: |
S. YA. Loginova, S. V. Borisevich, V. A. Maksimov, V. P. Bondarev |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 54, Iss 3-4, Pp 11-14 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| Popis: |
Cytotoxicity of chemotherapeutics (Ribavirin®, Remantadin® and Ingavirin®), interferon (Realdiron®) and interferon inductors (Larifan®, Ridostin®, Arbidol® and Cytarabin®) was investigated with the use of persistent and diploid cell cultures. Ingavirin® and Ribavirin® from the group of the chemotherapeutics and Razifan® and Ridostin® from the group of the interferon inducrors showed the lowest toxicity. Light microscopy revealed no visible cytopathic changes in the investigation cell cultures exposed to maximum concentrations (≥106 IU) of Realdiron®. In vivo acute toxicity investigation demonstrated that in a concentration of 106 IU per animal weight Realdiron® was not toxic for the albino mice and chinchilla rabbits. The maximum tolerance doses for the albino mice were the following: ≥3000 mg/kg of Ingavirin®, 401.25 mg/kg of Arbidol®, 170 mg/kg of Ribavirin®, ≥100 mg/kg of Larifan® and ≥100 mg/kg of Ridostin®. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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