Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes

Autor: Lucile Vigué, Giancarlo Croce, Marie Petitjean, Etienne Ruppé, Olivier Tenaillon, Martin Weigt
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31643-3
Popis: Predicting the effects of mutations in a species is a major challenge in genetics. Here, the authors investigate protein sequence landscapes using diverged E. coli sequences, to predict tolerated mutations and capture interactions between mutations.
Databáze: Directory of Open Access Journals