Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment
| Autor: | Jihye Lee, Jusung Lee, Geum Jin Kim, Inho Yang, Weihong Wang, Joo-Won Nam, Hyukjae Choi, Sang-Jip Nam, Heonjoong Kang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Marine Drugs, Vol 17, Iss 7, p 422 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1660-3397 17070422 |
| DOI: | 10.3390/md17070422 |
| Popis: | Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus. |
| Databáze: | Directory of Open Access Journals |
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