| Autor: |
Cristina Perez-Ternero, Beatriz Bermudez Pulgarin, Maria Alvarez de Sotomayor, Maria Dolores Herrera |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 26, Iss , Pp 610-621 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2016.08.037 |
| Popis: |
Rice bran has long been considered as a nutritional supplement in the prevention of cardiovascular diseases. ApoE−/− mice were fed high fat diet supplemented with 1 or 5% rice bran enzymatic extract (RBEE). In parallel, 100 ng/ml LPS induced human monocytes were treated with 20 µg/ml RBEE, ferulic acid (FA) or γ-oryzanol (γ-Ory). RBEE diet supplements reduced NF-κβ activation, TNF-α, COX-2 and iNOS expression and serum NO-derived metabolites. Additionally, NADPH oxidase subunits were downregulated, resulting in lower superoxide production, as evidenced by lower dihydroethidium fluorescence and oxLDL deposition in the aorta. RBEE, FA and γ-Ory reduced pro-inflammatory monocyte (CD14++ CD16+) phenotype and increased non-classical monocytes (CD14− CD16++). A shift towards M2 polarised macrophages was observed, leading to reduced IL-6 and TNF-α mRNA expressions. RBEE chronic consumption ameliorates atherosclerosis-related oxidative stress and inflammation showing its potential as nutritional supplement. FA moiety of γ-Ory was identified as the main responsible for the actions observed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect