| Autor: |
Diogo A. Tschoeke, Gisele L. Nunes, Rodrigo Jardim, Joana Lima, Aline S. R. Dumaresq, Monete R. Gomes, Leandro De Mattos Pereira, Daniel R. Loureiro, Patricia H. Stoco, Herbert Leonel De Matos Gliedes, Antonio Basilio De Miranda, Jeronimo Ruiz, André Pitaluga, Floriano P. Silva, Christian M. Probst, Nicholas J. Dickens, Jeremy C. Mottram, Edmundo C. Grisard, Alberto M. R. Dávila |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Evolutionary Bioinformatics, Vol 10 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1176-9343 |
| DOI: |
10.4137/EBO.S13759 |
| Popis: |
Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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