A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Autor:	Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Science
Zdroj:	Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Druh dokumentu:	article
ISSN:	2041-1723
DOI:	10.1038/s41467-021-24156-y
Popis:	The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a96a0ab6494b4682a6b6f2fb49128893 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ