| Autor: |
Masayuki Uchida, Orie Kobayashi, Chizuru Iwamoto |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 127, Iss 2, Pp 229-231 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2014.12.008 |
| Popis: |
Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of l-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1-13C]acetic acid and Barostat study, respectively, in rats. l-Tryptophan significantly decreased Cmax and AUC120min and delayed Tmax, indicating the inhibition of gastric emptying. l-Tryptophan significantly enhanced the gastric accommodation. These findings show that l-tryptophan may inhibit the gastric emptying through the enhanced gastric accommodation. Therefore, l-tryptophan may be useful for the therapy of postprandial dyspepsia, especially for early satiety. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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