Toxicity parameters of a new 1,2,4-triazole derivative when subcutaneously injected to guinea pigs
| Autor: | V. V. Zazharskyi, O. A. Bigdan, V. V. Parchenko, Y. V. Karpenko, N. M. Zazharska, Y. O. Mykhailiuk, O. M. Kulishenko, P. O. Davydenko, S. M. Kulish, B. V. Gutyj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Regulatory Mechanisms in Biosystems, Vol 15, Iss 1, Pp 166-170 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2519-8521 2520-2588 |
| DOI: | 10.15421/022424 |
| Popis: | The results of the literature analysis indicate a wide spectrum of biological activity of 1,2,4-triazole derivatives. Low toxicity, reactivity, and high biological activity of 1,2,4-triazole derivatives make this class of compounds very attractive. The obtained data determine the relevance of further studies of 1,2,4-triazole derivatives to find new highly effective biologically active substances that can become the basis for new medicines. Our further work aimed to study some toxicity parameters of 3-(3-fluorophenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b][1,3,4] thiadiazine when administered subcutaneously to guinea pigs, which is a necessary condition for further implementation in practice of this compound. In this work, we observed an absence of toxic effects after a single subcutaneous injection to guinea pigs at a dose of 40 mg/kg experimental drug. The results of macro- and microscopic examinations of internal organs 14 days after a single subcutaneous injection of the studied compound at a dose of 20, 40 mg/kg showed the absence of any anatomical and morphological disorders in the tissue structures of guinea pigs. The calculated value indicates a high degree of safety of 3-(3-fluorophenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b][1,3,4] thiadiazine and its prospects for use in veterinary practice as an effective and safe tuberculocidal agent. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|