Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy

Autor: Aram G. Gyulkhandanyan, Marina H. Paronyan, Anna G. Gyulkhandanyan, Karapet R. Ghazaryan, Marina V. Parkhats, Boris M. Dzhagarov, Maria V. Korchenova, Ekaterina N. Lazareva, Elena S. Tuchina, Grigor V. Gyulkhandanyan, Valery V. Tuchin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Innovative Optical Health Sciences, Vol 15, Iss 1, Pp 2142007-1-2142007-16 (2022)
Druh dokumentu: article
ISSN: 1793-5458
1793-7205
17935458
DOI: 10.1142/S1793545821420074
Popis: Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms. Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia. The aim of this work was to determine and test the most effective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms. It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria, including the methicillin-resistant S. aureus strain. Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs. The effectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation. It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors: the presence in the porphyrin macrocycle of a positive charge (+4), a central metal atom (Zn2+) and hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen. The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins can find wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.
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