| Autor: |
M Castelnovo, D Muriaux, C Faivre-Moskalenko |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
New Journal of Physics, Vol 15, Iss 3, p 035028 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1367-2630 |
| DOI: |
10.1088/1367-2630/15/3/035028 |
| Popis: |
Morphologic diversity is observed across all families of viruses. However, these supra-molecular assemblies are produced most of the time in a spontaneous way through complex molecular self-assembly scenarios. The modeling of these phenomena remains a challenging problem within the emerging field of physical virology . We present in this work a theoretical analysis aiming at highlighting the particular role of configuration entropy in the control of viral particle size distribution. Specializing this model to retroviruses such as HIV-1, we predict a new mechanism of entropic control of both RNA uptake into the viral particle and of the particle's size distribution. Evidence of this peculiar behavior has recently been reported experimentally. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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