| Autor: |
Tonatiuh Abimael Baltazar-Díaz, Luz Alicia González-Hernández, Juan Manuel Aldana-Ledesma, Donovan Cortina-Romero, Marcela Peña-Rodríguez, Alejandra Natali Vega-Magaña, Sara Minia Zepeda-Morales, Rocío Ivette López-Roa, Susana Del Toro-Arreola, Miriam Bueno-Topete |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 28, Iss , Pp 101016- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2023.101016 |
| Popis: |
Introduction and Objectives: Alterations in the intestinal microbiota in decompensated cirrhosis are recognized as being critical in clinical evolution. The onset of hepatic encephalopathy (HE) worsens the prognosis. Metabolic functions related to intestinal microbiota, such as ammonia production and imbalance of amino acid biosynthesis, are believed to play a key role on the pathophysiology of HE. This study aimed to evaluate the composition and functions of the intestinal microbiota in patients with decompensated cirrhosis and HE. Materials and Methods: Fecal samples from 31 decompensated cirrhotic patients (20 with HE, 11 without HE) and 18 age-balanced healthy controls (HC) were included. Microbial composition was characterized by 16S rRNA sequencing and analyzed using QIIME2. Metabolic pathways were inferred by PICRUSt2. SCFAs quantification was performed by gas chromatography (GC). Results: Intestinal microbiota in HE group was characterized by a decreased α-diversity, compared to no-HE group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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