Application of donor predicted heart mass in heart transplant recipients with left ventricular assist device

Autor: Ross M. Reul, Jr, MD, Qiudong Chen, MD, Joshua L. Chan, MD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JHLT Open, Vol 6, Iss , Pp 100150- (2024)
Druh dokumentu: article
ISSN: 2950-1334
DOI: 10.1016/j.jhlto.2024.100150
Popis: Background: An association between predicted heart mass (PHM) and post heart transplantation outcomes has been well established; however, there is limited data on the effect of donor PHM on recipients bridged with a durable left ventricular assist device (LVAD). This retrospective observational study seeks to challenge the theoretical benefit of oversizing donor hearts for recipients bridged with LVADs. Methods: Analysis of the United Network for Organ Sharing database revealed 10,806 adult patients with 1 of 3 durable LVADs (HeartMate 2, HeartMate 3 [HM3], HeartWare Ventricular Assist Device) between January 1, 2015 and December 31, 2021. Baseline characteristics were compared between 7 equally sized groups based on donor-to-recipient PHM. Univariable and multivariable Cox regression analyses were constructed to evaluate the effect of PHM size-matching on the primary outcome of 1-year post-transplant survival. Further analyses were performed specifically on HM3 patients and with PHM as a continuous variable. Results: Multivariable analysis revealed that severely undersized donor hearts (PHM ratio
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