Chemical screening and mosquitocidal activity of essential oil derived from Mikania scandens (L.) Willd. against Anopheles gambiae Giles and their non-toxicity on mosquito predators
| Autor: | Narayanaswamy Radhakrishnan, Sengodan Karthi, Pandiyan Raghuraman, Raja Ganesan, Kumaraswamy Srinivasan, Edward-Sam Edwin, Selvaraj Ganesh-Kumar, Norhaizan Mohd Esa, Sengottayan Senthil-Nathan, Prabhakaran Vasantha-Srinivasan, Patcharin Krutmuangh, Mona S. Alwahibi, Mohamed Soliman Elshikh |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | All Life, Vol 16, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2689-5307 26895293 |
| DOI: | 10.1080/26895293.2023.2169959 |
| Popis: | In-vitro chemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens (L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiae was investigated. GC-MS analysis evidenced a total of 12 bio-active compounds, and maximum at α-bisabolol (39.34%) followed by stigmasterol (13.45%) respectively. The larvicidal activity of CVO-MS against the malarial vector An. gambiae evidenced that the mortality rate was prominent at the maximum dosage of 1000 ppm. The Median Lethal Concentration (LC50) of CVO-MS was established at 488 ± 2.45 ppm, respectively. Enzyme inhibition assay showed that the CVO-MS delivers a significant upsurge in the level of CYP450, GST, and a decline in the level of α-β carboxylesterase activity in both the third and fourth instar (p ≤ 0.0001). The gut-histological examination of CVO-MS showed that there is severe damage in the mid-gut tissues, especially epithelial layer (EL), gut-lumen (GL), and peritrophic membrane (pM). The non-target screening against the mosquito predators (A. bouvieri, D. indicus, and third instar larvae of Tx. splendens) suggests that CVO-MS showed less toxicity as compared to Pestanal® (1 ppm) respectively. The present study has paved a new insight in understanding the bioactivity of CVO-MS as a potential larvicidal agent of malarial vector and non-toxic against mosquito predators. |
| Databáze: | Directory of Open Access Journals |
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