Epigenetic Regulation of Hepatocellular Carcinoma Progression through the mTOR Signaling Pathway

Autor: Mengnan Guo, Ning Li, Jianxia Zheng, Wei Wang, Yan Wu, Xu Han, Jiapei Guo, Weixi Chen, Zekun Bai, Wen Bai, Jinghua Wu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2291-2789
2291-2797
DOI: 10.1155/2021/5596712
Popis: Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is an aggressive tumor with a high mortality rate because of the limited systemic and locoregional treatment modalities. The development and progression of HCC depend on epigenetic changes that result in the activation or inhibition of some signaling pathways. The mTOR signaling pathway is essential for many pathophysiological processes and is considered a major regulator of cancer. Increasing evidence has shown that epigenetics plays a key role in HCC biology by regulating the mTOR signaling pathway. Therefore, epigenetic regulation through the mTOR signaling pathway to diagnose and treat HCC will become a very promising strategy.
Databáze: Directory of Open Access Journals
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