Postoperative Neutrophil to Lymphocyte and Platelet Ratio and Delayed Graft Function
| Autor: | João Oliveira, João Missa, Joana Gameiro, Alice Santana, José António Lopes, Marta Neves |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Revista Portuguesa de Nefrologia e Hipertensão, Vol 37, Iss 4, Pp 185-191 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0872-0169 2183-1289 |
| DOI: | 10.32932/pjnh.2023.11.261 |
| Popis: | Introduction: Delayed graft function (DGF), an outcome for which inflammation is critical, has been associated with worse outcomes after kidney transplantation (KT). The neutrophil to lymphocyte and platelet (NLP) ratio is a biomarker of systemic inflammation. We assessed postoperative NLP ratio applicability as an early predictor of DGF in KT patients. Methods: Retrospective cohort of adult patients submitted to KT at our unit, between 1 January 2010 and 31 December 2020. NLP was calculated at 24 hours post-KT. Primary outcome was development of DGF. Logistic regression was calculated to determine significant factors which may have contributed to DGF. Results: We included 527 patients with a mean age of 49.9 ± 12.8 years. In 47.8% of patients expanded criteria donors were used, and in 3.6% non-heart-beating donors. DGF occurred in 17.8% of patients. Mean post-KT NLP was higher in patients submitted to induction therapy with lymphocyte depleting antibodies (50.2±40.3 vs 11.9±7.4 with basiliximab, p |
| Databáze: | Directory of Open Access Journals |
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