Staphylococcal Vaccine Antigens related to biofilm formation

Autor:	Bahman Mirzaei, Ryhaneh Babaei, Sina Valinejad
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	candidate vaccines biofilm device-related infection immunotherapy prophylaxis nosocomial pathogen staphylococcus aureus staphylococcus epidermidis Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 17, Iss 1, Pp 293-303 (2021)
Druh dokumentu:	article
ISSN:	2164-5515 2164-554X 21645515
DOI:	10.1080/21645515.2020.1767449
Popis:	The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9656602d183d4e7c929f073008ea741d Zobrazit plný text záznamu View record in DOAJ