Inflammatory Responses to Opisthorchis viverrini Infection in Animal Models: A comparison between susceptible and non-susceptible hosts in different anatomical locations

Autor: Sirikachorn Tangkawattana, Watcharapol Suyapoh, Theerayut Thongrin, Woro Danur Wendo, Kanin Salao, Sutas Suttiprapa, Prasert Saichua, Prasarn Tangkawattana
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Open Veterinary Journal, Vol 14, Iss 2, Pp 664-673 (2024)
Druh dokumentu: article
ISSN: 2226-4485
2218-6050
DOI: 10.5455/OVJ.2024.v14.i2.6
Popis: Background: Inflammation caused by Opisthorchis viverrini infection increases the risk of cholangitis, cholecystitis, and lead to bile duct cancer (cholangiocarcinoma or CCA). However, only certain infected individuals are susceptible to CCA, suggesting the involvement of host factors in cancer development. Additionally, there are reports indicating differences in the locations CCA. Aim: This study aims to investigate cellular inflammatory responses in the common bile duct (CB), intrahepatic bile duct (IHB), and gallbladder (GB) in susceptible and non-susceptible hosts following O. viverrini infection. Methods: Thirty Syrian golden hamsters (a susceptible host) and 30 BALB/c mice (a non-susceptible host) infected with O. viverrini were studied at 6 time points (5 animals per group). Histopathological evaluations were conducted on samples from the IHB, CB, and GB. Inflammatory cell infiltration was quantitatively assessed and compared between groups and time points. Statistical analysis was performed using one-way ANOVA, with a significance level of p [Open Vet J 2024; 14(2.000): 664-673]
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