Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins

Autor:	Antigoni Kotali, Despina A. Nasiopoulou, Constantinos A. Tsoleridis, Philip A. Harris, Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	antioxidants 3-acetyl-4-hydroxycoumarin acyl hydrazones DPPH trolox lipid peroxidation soybean lipoxygenase Organic chemistry QD241-441
Zdroj:	Molecules, Vol 21, Iss 2, p 138 (2016)
Druh dokumentu:	article
ISSN:	1420-3049 85255394
DOI:	10.3390/molecules21020138
Popis:	A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d962c852553946439b8ea2ad67162ac4 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF