Autor: |
Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu, Ninghong Song |
Jazyk: |
angličtina |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
Cancer Cell International, Vol 19, Iss 1, Pp 1-8 (2019) |
Druh dokumentu: |
article |
ISSN: |
1475-2867 |
DOI: |
10.1186/s12935-019-0788-z |
Popis: |
Abstract Background The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Methods Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated. Results 3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P |
Databáze: |
Directory of Open Access Journals |
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