Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis

Autor:	Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu, Ninghong Song
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Lin-28 Prognosis Human tumors Biomarker Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 19, Iss 1, Pp 1-8 (2019)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-019-0788-z
Popis:	Abstract Background The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Methods Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated. Results 3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9622e6b7d6364adf9b6dace76831f79c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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