Is the platelet-to-lymphocyte ratio a new prognostic marker in multiple myeloma?

Autor: Serife Solmaz, Ozcan Uzun, Celal Acar, Omur Gokmen Sevindik, Ozden Piskin, Hayri Guner Ozsan, Fatih Demirkan, Bulent Undar, Ahmet Alacacioglu, Mehmet Ali Ozcan, Inci Alacacioglu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Laboratory Physicians, Vol 10, Iss 04, Pp 363-369 (2018)
Druh dokumentu: article
ISSN: 0974-2727
0974-7826
DOI: 10.4103/JLP.JLP_36_18
Popis: BACKGROUND: Recent reports showed neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. MATERIALS AND METHODS: We retrospectively examined the PLR, NLR, and MLR in a cohort of 186 newly diagnosed multiple myeloma (MM) patients. This study investigated the prognostic relevance of NLR, PLR, and MLR in MM patients. NLR, PLR, and MLR were calculated from whole blood counts before therapy. The Kaplan–Meier curves and multivariate Cox models were used for the evaluation of survival. RESULTS: Applying cutoff of 1.9 (NLR), 120.00 (PLR), and 0.27 (MLR), decreased PLR showed a negative impact on the outcome. Decreased PLR is an independent predictor for PFS and OS. There were no significant differences in median survival between the high and low NLR (P = 0.80) and MLR (P = 0.87) groups. CONCLUSIONS: In this study, thrombocytopenia and low PLR are associated with poor survival in MM patients does this P value apply to thrombocytopenia or low PLR and may serve as the cost-effective prognostic biomarker.
Databáze: Directory of Open Access Journals
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