| Autor: |
Lihua Yang, Guocheng Zhang, Lusheng Huang, Xiaoling Ren, Yanqi Su, Chengxiu Wang, Yuanbin Shi, Liao Li, Hui Shan, Jing Chen, Jianxin Xiong, Xue Xue, Shaofeng Song, Li Zhao, Shuhua An, Haiming Yu, Hong Cao, Lin Zhao, Ming Li, Xiaocui Sheng, Yajun Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Jornal de Pediatria, Vol 97, Iss 6, Pp 617-622 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0021-7557 |
| DOI: |
10.1016/j.jped.2020.12.005 |
| Popis: |
Objective: To investigate the impact of recombinant human interferon α1b (rhIFNα1b) treatment in infants hospitalized with lower respiratory tract infections on subsequent wheezing. Methods: The clinical data of infants (n = 540) with viral pneumonia, wheezy bronchitis, or bronchiolitis hospitalized in 19 Chinese hospitals from June 2009 to June 2015 were retrospectively analyzed. The parameters relevant to wheezing episodes within the last year were collected by telephone and questionnaires. The rhIFNα1b treatment group (n = 253) and control group (n = 287) were compared in terms of wheezing episodes within the last year. Moreover, the wheezing group (95 cases) and non-wheezing group (445 cases) were compared. Results: Out of 540 cases, 95 (17.6%) experienced wheezing episodes, 13.8% (35/253) cases treated with rhIFNα1b, and 20.9% (60/287) cases without rhIFNα1b experienced wheezing episodes within the last year. The rhIFNα1b treatment significantly improved wheezing episodes within the last year, compared with the control peers (p = 0.031). Single-factor regression showed statistically significant differences between the wheezing and non-wheezing groups in terms of age, rhIFNα1b use, childhood and family history of allergy, housing situation, and feeding history (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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