Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms

Autor:	Bahman Emami, Farzaneh Shakeri, Vahideh Ghorani, Mohammad Hossein Boskabady
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	beta adrenergic stimulation muscarinic receptor inhibition calcium channel blocking Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmaceutical Biology, Vol 55, Iss 1, Pp 2248-2258 (2017)
Druh dokumentu:	article
ISSN:	1388-0209 1744-5116 13880209
DOI:	10.1080/13880209.2017.1400079
Popis:	Context: Turmeric is a spice obtained from the root of Curcuma longa L. (Zingiberaceae) with anti-aging, anticancer, anti-Alzheimer’s disease, antioxidant and other medicinal properties. Objective: The relaxant effect of C. longa on rat tracheal smooth muscle and its possible mechanisms were investigated in this study. Materials and methods: The relaxant effects of four cumulative concentrations of hydro-ethanol extract of C. longa (6.25, 12.5, 25, 50 mg/mL) were studied on tracheal smooth muscle precontracted by methacholine or KCl in non-incubated or incubated with different substances including propranolol, diltiazem, L-NAME, glibenclamide, atropine, chlorpheniramine, indomethacin and papaverine. The duration of the study was 84 days. Results: In non-incubated tracheal smooth muscle, the extract of C. longa showed significant concentration-dependent relaxant effects (p
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