| Autor: |
Hilda M. Rodríguez Montero, Elizabeth Reyes Reyes, Tania M. Escalante Leyva, Raidel Correa Aguila, Antonio Torres Valle, Elizabeth B. Cuétara-Lug |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacy & Pharmacognosy Research, Vol 6, Iss 6, Pp 433-447 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0719-4250 |
| Popis: |
Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow up of cancer in Cuba. Cancer treatment is mainly by three methods: surgery, radiotherapy and chemotherapy. Pharmacological treatments involve the use of dangerous substances such as cytostatics, the handling of which threat the health of the occupationally exposed staff. Aims: To evaluate a biomarker of genotoxicity indicative of DNA damage in the biomonitoring of occupational risks associated with the administration of antineoplastic drugs to hospitalized patients. Methods: The determination of the frequency of micronuclei, in cells of the exfoliated oral mucosa was determined (Micronucleus test) in subjects who administer cytostatic drugs at the institute and a control group formed by administrative personal. Results: Present results evidenced that all exposed subjects possess the same DNA damage that non-exposed-ones. Such results are in concordance with the proper use of primary protection barriers and the adhesion to normalized operational procedures. Conclusions: The frequency of micronuclei is a useful biomarker for assessing DNA damage associated with the administration of antineoplastic drugs. The risk perception analysis (RISKPERCEP) in occupationally exposed subjects complements the occupational safety monitoring. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
