| Autor: |
Bo Han, Hyeon‐Cheol Lee‐Okada, Momoko Ishimine, Hajime Orita, Keiko Nishikawa, Tetsuya Takagaki, Kazunori Kajino, Takehiko Yokomizo, Okio Hino, Toshiyuki Kobayashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
FEBS Open Bio, Vol 10, Iss 11, Pp 2375-2387 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1002/2211-5463.12985 |
| Popis: |
Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction of carboxylesterase 2 (CES2), a CPT‐11‐activating enzyme, in MM. The level of CES2 mRNA was greatly increased on treatment with nutlin‐3a. A combination of CPT‐11 and nutlin‐3a inhibited the growth of MM cells more effectively than either drug alone. Knocking down CES2 in MM cells reduced the effect of the drug combination, and its forced expression in MESO4 cells enhanced the growth inhibitory activity of CPT‐11 in the absence of nutlin‐3a. Enhancement of the growth inhibitory activity of CPT‐11 by nutlin‐3a suggests a possible new combinatorial MM chemotherapy regimen. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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