| Autor: |
Stefanie Gamradt, Helge Hasselmann, Aline Taenzer, Jelena Brasanac, Victoria Stiglbauer, Arne Sattler, Max Sajitz-Hermstein, Sylwia Kierszniowska, Caren Ramien, Jan Nowacki, Lea Mascarell-Maricic, Katja Wingenfeld, Dominique Piber, Andreas Ströhle, Katja Kotsch, Friedemann Paul, Christian Otte, Stefan M. Gold |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 24, Iss 11, Pp 103312- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2021.103312 |
| Popis: |
Summary: Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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