The effect of donor against recipient one-way HLA mismatch on liver transplantation outcomes from a multicenter registry analysis

Autor: Sunghae Park, Young Rok Choi, Dong Jin Joo, Young Kyoung You, Bong-Wan Kim, Yang Won Nah, Jai Young Cho, Tae-Seok Kim, Geun Hong, Man Ki Ju, Suk-Won Suh, Jae Do Yang, Pyoung Jae Park, Jaehong Jeong, Ju Ik Moon, Dong-Sik Kim, Jinsoo Rhu, The Korean Organ Transplantation Registry Study Group
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-023-49178-y
Popis: Abstract Donor against recipient one-way Human leukocyte antigen (HLA) mismatch (D → R one-way HLA MM) seemed strongly associated with graft-versus-host disease (GVHD). The aim of this study is to investigate the relevance of D → R one-way HLA MM in outcome of liver transplantation (LT). We retrospectively analyzed 2670 patients in Korean Organ Transplantation Registry database between April 2014 and December 2020. The patients were categorized into two groups whether D → R one-way HLA MM or not and evaluated the outcomes of LT between the two groups. 18 patients were found to be D → R one-way HLA MM. The incidence of GVHD (0.3% vs. 22.2%, p
Databáze: Directory of Open Access Journals
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