| Autor: |
Nafari Maedeh, Asri Nastaran, Rostami-Nejad Mohammad, Forouzesh Flora, Ehsani-Ardakani Mohammad Javad, Jahani-Sherafat Somayeh, Rezaei-Tavirani Mostafa, Aghdaei Hamid Asadzadeh |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Romanian Journal of Internal Medicine, Vol 60, Iss 3, Pp 166-172 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2501-062X |
| DOI: |
10.2478/rjim-2022-0011 |
| Popis: |
Introduction: The microRNA-326 (miR-326) gene, by targeting ETS Proto-Oncogene 1 (ETS1), regulates the differentiation and interleukin-17A production of T helper 17 (Th17) cells. Celiac disease (CD) is an intestinal autoimmune disorder, in which the cascade of Th17 cells plays an important role in its pathogenicity. The aim of this study was to evaluate the expression changes of miR-326 and its two target genes ETS1 and IL-17A in celiac disease patients under a gluten-free diet (GFD). We expected the expression of miR-326 and IL-17A gene to decrease, and the expression of the ETS1 gene to increase, following the adherence to GFD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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