Impact of modification to DSM-5 criterion A for hypomania/mania in newly diagnosed bipolar patients: findings from the prospective BIO study

Autor: Mette U. Fredskild, Sharleny Stanislaus, Klara Coello, Sigurd A. Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Trisha Suppes, Maj Vinberg, Lars Vedel Kessing
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-10 (2021)
Druh dokumentu: article
ISSN: 2194-7511
DOI: 10.1186/s40345-020-00219-9
Popis: Abstract Background DSM-IV states that criterion A for diagnosing hypomania/mania is mood change. The revised DSM-5 now states that increased energy or activity must be present alongside mood changes to diagnose hypomania/mania, thus raising energy/activity to criterion A. We set out to investigate how the change in criterion A affects the diagnosis of hypomanic/manic visits in patients with a newly diagnosed bipolar disorder. Results In this prospective cohort study, 373 patients were included (median age = 32; IQR, 27–40). Women constituted 66% (n = 245) of the cohort and 68% of the cohort (n = 253) met criteria for bipolar type II, the remaining patients were diagnosed bipolar type I. Median number of contributed visits was 2 per subject (IQR, 1–3) and median follow-up time was 3 years (IQR, 2–4). During follow-up, 127 patients had at least one visit with fulfilled DSM-IV criterion A. Applying DSM-5 criterion A reduced the number of patients experiencing a hypomanic/manic visit by 62% at baseline and by 50% during longitudinal follow-up, compared with DSM-IV criterion A. Fulfilling DSM-5 criterion A during follow-up was associated with higher modified young mania rating scale score (OR = 1.51, CL [1.34, 1.71], p
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