| Autor: |
Felipe Cicci Farinha Restini, Tarraf Torfeh, Souha Aouadi, Rabih Hammoud, Noora Al-Hammadi, Maria Thereza Mansur Starling, Cecília Felix Penido Mendes Sousa, Anselmo Mancini, Leticia Hernandes Brito, Fernanda Hayashida Yoshimoto, Nildevande Firmino Lima-Júnior, Marcello Moro Queiroz, Ula Lindoso Passos, Camila Trolez Amancio, Jorge Tomio Takahashi, Daniel De Souza Delgado, Samir Abdallah Hanna, Gustavo Nader Marta, Wellington Furtado Pimenta Neves-Junior |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-78189-6 |
| Popis: |
Abstract Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation. Diagnostic magnetic resonance (MR) images in public repositories were used for training. The algorithm created was validated in data from a single institution. All images were segmented according to widely used guidelines for radiotherapy planning and combined with clinical evaluations from neuroradiology experts. Radiomic features and clinical impressions were extracted, tabulated, and used for modeling. Feature selection methods were used to identify relevant phenotypes. A total of 100 patients were used for training and 46 for validation. A total of 343 features were extracted. Eight feature selection methods produced seven independent predictive frameworks. The top-performing ML model was a model post-Least Absolute Shrinkage and Selection Operator (LASSO) feature selection reaching accuracy (ACC) of 0.82, an area under the curve (AUC) of 0.81, a recall of 0.75, and a precision of 0.75. This study demonstrates that integrating clinical and radiotherapy-derived AI-driven phenotypes can predict MGMT methylation. The framework addresses constraints that limit molecular diagnosis access. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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