| Autor: |
Lorena Vigón, Sonia Vázquez-Morón, Juan Berenguer, Juan González-García, Ma Ángeles Jiménez-Sousa, Josep M. Guardiola, Manuel Crespo, Ignacio de Los Santos, Miguel A. Von Wichmann, Ana Carrero, María Belén Yélamos, Julián Gómez, Salvador Resino, Isidoro Martínez, The GESIDA 3603b Cohort Study Group |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-019-48592-5 |
| Popis: |
Abstract The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with peg-IFNα + ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against five JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVR. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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