Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
| Autor: | Ana Luiza Pamplona Mosimann, Juliano Bordignon, Giovanny Camacho Antevêre Mazzarotto, Maria Cristina M Motta, Federico Hoffmann, Claudia Nunes Duarte dos Santos |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 3, Pp 285-292 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1678-8060 0074-0276 |
| DOI: | 10.1590/S0074-02762011000300006 |
| Popis: | Brevidensoviruses have an encapsidated, single-stranded DNA genome that predominantly has a negative polarity. In recent years, they have received particular attention due to their potential role in the biological control of pathogenic arboviruses and to their unnoticed presence in cell cultures as contaminants. In addition, brevidensoviruses may also be useful as viral vectors. This study describes the first genetic and biological characterization of a mosquito densovirus that was isolated in Brazil; moreover, we examined the phylogenetic relationship between this isolate and the other brevidensoviruses. We further demonstrate that this densovirus has the potential to be used to biologically control dengue virus (DENV) infection with in vitro co-infection experiments. The present study provides evidence that this densovirus isolate is a fast-spreading virus that affects cell growth and DENV infection. |
| Databáze: | Directory of Open Access Journals |
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