Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

Autor:	Wen-Hao Fan, Zong-Gui Yu, Hui Zhang, Yong-Nan Xu, Li-Bo Zou, Yi-Xia Gong, Hui-Ming Hua, Jian-Yu Liu, Ying-Li Guan
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Pulsatilla cernua saponin neuroprotective effect Alzheimer’s disease β-amyloid Organic chemistry QD241-441
Zdroj:	Molecules, Vol 17, Iss 5, Pp 5520-5531 (2012)
Druh dokumentu:	article
ISSN:	17055520 1420-3049
DOI:	10.3390/molecules17055520
Popis:	Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid25–35 (Aβ25–35) on human neuroblastoma SH-SY5Y cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/958a61d60eff4060931a890bc2fce4b7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF