| Autor: |
Minami Yoshihara, Chisaki Asatsuma, Ayuna Masuko, Keiya Iwaasa, Yuki Saito-Matsuzawa, Hideyuki Sone, Shin Kamiyama |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Biologics, Vol 3, Iss 3, Pp 187-197 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-8449 |
| DOI: |
10.3390/biologics3030010 |
| Popis: |
Collagen peptides (CPs) are food-derived peptides that possess a variety of bioactive properties. Our study investigates the effects of CP on pulmonary fibrosis in bleomycin (BLM)-treated mice. C57BL/6J mice were subcutaneously injected with BLM for two weeks followed by a three-week experimental diet containing 25 mg/g of CP derived from chicken feet. Supplementation with CP suppressed the increase in lung weight and disruption of lung architecture observed in mice treated with BLM. BLM-treated mice also exhibited higher hydroxyproline content and increased expression levels of type I and III collagen subunit genes in the lungs. CP supplementation exerted no effect on these collagen-related factors; however, it significantly suppressed the gene expression of fibronectin and inflammation-related molecules in the lungs of BLM-treated mice. These findings suggest that CP administration prevents the development of pulmonary fibrosis by acting as an anti-inflammatory agent. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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