Lipase-mediated epoxidation of alkenes in supercritical carbon dioxide
| Autor: | Jiaxin Zhang, Wenwei Qian, Chunyu Wang, Ziyi Cao, Shanshan Chen, Liu Zhang, Yang Zhang, Lei Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Green Chemistry Letters and Reviews, Vol 11, Iss 4, Pp 508-512 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1751-8253 1751-7192 17518253 |
| DOI: | 10.1080/17518253.2018.1543456 |
| Popis: | In this work, supercritical carbon dioxide was used as reaction media in the lipase-mediated epoxidation of alkenes for the first time. Under the optimal conditions (alkene (1 mmol), novozym 435 (15 mg), H2O2 (50% aqueous solution, 1.4 mmol), n-caprylic acid (0.05 mmol), 40°C, scCO2 (10 MPa, 25 mL)), high yields (83–98%) of epoxidation of alkenes could be obtained in a short reaction time. Furthermore, novozym 435 exhibited a satisfactory reusability in the epoxidations. Thus, this work not only presents a green and mild method of lipase-mediated epoxidation with higher yield and reaction rate than other lipase-mediated routes ever reported but also expands the application of supercritical carbon dioxide in enzyme catalytic promiscuity. |
| Databáze: | Directory of Open Access Journals |
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