| Autor: |
Yi Liu, Brian Debo, Mingfeng Li, Zhennan Shi, Wanqiang Sheng, Yang Shi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-27179-7 |
| Popis: |
Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in preclinical cancer models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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