Probiotic intervention improves gingival status and influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults
| Autor: | Heli Jäsberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Oral Microbiology, Vol 9, Iss 0 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2000-2297 20002297 |
| DOI: | 10.1080/20002297.2017.1325214 |
| Popis: | The effect of orally administered Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG on the amount of plaque, gingival inflammation, oral microbiota and salivary mutans streptococci, as well as on levels of Matrix Metalloproteinases (MMP)-8, MMP-9, and of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in healthy adults was studied. The study was a randomized controlled trial with a four-week study period. The saliva samples were collected and clinical parameters measured at the baseline and at the end of the study. In the probiotic group, the plaque and gingival indices reduced, salivary MMP-9 levels increased (p=0.007) and TIMP-1 levels decreased (p=0.003) significantly during the intervention. These changes were not observed in control group. In addition, the probiotic intervention had no effect on salivary microbiota. To conclude, improved gingival status with increased MMP-9 and decreased TIMP-1 levels in saliva may indicate that probiotics have immunomodulatory effects in the oral cavity. |
| Databáze: | Directory of Open Access Journals |
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