Effect of Sodium Salicylate on the Viscoelastic Properties and Stability of Polyacrylate-Based Hydrogels for Medical Applications

Autor: Zuzana Kolarova Raskova, Martina Hrabalikova, Vladimir Sedlarik
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: International Journal of Polymer Science, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 1687-9422
1687-9430
DOI: 10.1155/2016/5614687
Popis: Investigation was made into the effect exerted by the presence of sodium salicylate (0–2 wt.%), in Carbomer-based hydrogel systems, on processing conditions, rheological and antimicrobial properties in tests against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains, and examples of yeast (Candida albicans) and mould (Aspergillus niger). In addition, the work presents an examination of long-term stability by means of aging over one year the given hydrogels at 8°C and 25°C. The results show that 0.5 wt.% NaSal demonstrated a noticeable effect on the hydrogel neutralization process, viscosity, and antimicrobial properties against all of the tested microorganisms. The long-term stability studies revealed that hydrogels can maintain antimicrobial activity as well as viscosity to a degree that would be sufficient for practical use.
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