Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Autor: Salah Aref, Omnyia Khaled, Nadia El Menshawy, Emad Azmy, Mohamed Aref, Osama Salama, Nada Khaled
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 2589-0409
DOI: 10.1186/s43046-024-00209-3
Popis: Abstract Objective This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients’ outcomes. Methods SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls. Results Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P =
Databáze: Directory of Open Access Journals