Autor: |
Fabin Lin, Xuanjie Chen, Yisen Shi, Kaitai Yang, Guoping Hu, Weijiang Zhuang, Yifei Lin, Tingting Huang, Qinyong Ye, Guoen Cai, Xilin Wu |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
BMC Public Health, Vol 24, Iss 1, Pp 1-9 (2024) |
Druh dokumentu: |
article |
ISSN: |
1471-2458 |
DOI: |
10.1186/s12889-024-18588-6 |
Popis: |
Abstract Introduction Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early life, including smoking during adolescence and maternal smoking during pregnancy, can affect adolescent development and lead to several negative outcomes. However, the association between early-life tobacco exposure and stroke is not known. Methods In this prospective cohort study, for the analyses involving exposure to maternal smoking during pregnancy and age of smoking initiation, we included 304,984 and 342,893 participants, respectively., respectively from the UK Biobank. Cox proportional hazard regression model and subgroup analyses were performed to investigate the association between early-life tobacco exposure and stroke. Mediation analyses were performed to identify the mediating role of biological aging in the association between early tobacco exposure and stroke. Results Compared with participants whose mothers did not smoke during pregnancy, participants whose mothers smoked during pregnancy showed an 11% increased risk of stroke (HR: 1.11, 95% CI: 1.05–1.18, P |
Databáze: |
Directory of Open Access Journals |
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