Bioinspired bioartifical polymer hybrid composites for propolis vaginal delivery I: formulation development and optimization of gelling temperature using experimental design
| Autor: | Maja Simonoska-Crcarevska, Ana Zafirovska-Gapkovska, Kristina Mladenovska, Renata Slavevska Raicki, Nikola Geskovski, Simona Dimcevska, Marija Glavas-Dodov |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Makedonsko Farmacevtski Bilten, Vol 59, Iss (1, 2), Pp 33-40 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1409-8695 1857-8969 |
| Popis: | Polymer hybrid composites for propolis vaginal delivery were developed and optimized in term of gelling temperature (Tg) using experimental design studies. Formulation of intelligent delivery system, with in situ gelling and controlled release properties, was carried out by bioartificial blending of chitosan and poloxamers, Lutrol F127 and Lutrol F68. Response-surface, Box-Behnken, experimental design was applied for determination of key factors influencing Tg. Influence of Lutrol F127 concentration, Lutrol F68/Lutrol F127 mass ratio and volume of simulated vaginal fluid was evaluated. Derived correlations enabled formulation optimization in term of Tg (32 °C). The model was cross-validated. Confirmation report and relative error percent of predicted and experimental values were obtained. |
| Databáze: | Directory of Open Access Journals |
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