Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats
| Autor: | Kazumi SHIMADA, Sakiko HARA, Seijirow GOYA, Ahmed S. MANDOUR, Pitipat KITPIPATKUN, Lina HAMABE, Akiko UEMURA, Joe TAKIZAWA, Ryou TANAKA |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 27, Iss 5, Pp 567-573 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1309-2251 95149899 |
| DOI: | 10.9775/kvfd.2021.25867 |
| Popis: | Butyric acid bacteria (BAB) are the primary intestinal flora present in all mammalian digestive tracts. Prior studies have found the association between decreased intestinal BAB population and development of diabetes, and BAB was suggested as a new treatment of type 2 diabetes. However, few studies have examined the effect of BAB on type 1 diabetes (DM1), which is frequently diagnosed in pet animals. Therefore, the aim of this study was to examine the therapeutic effects of BAB culture solution in the DM1 model. Thirty female rats were included for induction of DM1 by alloxan (200 mg/kg, IP). After one week, DM1 was developed in 13 rats (blood glucose level >300 mg/dL) which were then treated with BAB culture solution at a dose rate of 300 μL/kg/day for two weeks. The result revealed a reduction in blood glucose level (P |
| Databáze: | Directory of Open Access Journals |
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