| Autor: |
Akane Kanasaki, Zhe Jiang, Takuya Mizokami, Bungo Shirouchi, Tetsuo Iida, Yasuo Nagata, Masao Sato |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 60, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.103429 |
| Popis: |
d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary d-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of d-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% d-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, d-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary d-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, d-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect