A Preliminary Study of the Therapeutic Role of Human Early Fetal Aorta-derived Endothelial Progenitor Cells in Inhibiting Carotid Artery Neointimal Hyperplasia

Autor: Rong-Wei Xu, Wen-Jian Zhang, Jian-Bin Zhang, Jian-Yan Wen, Meng Wang, Hong-Lin Liu, Lin Pan, Chang-An Yu, Jin-Ning Lou, Peng Liu
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Chinese Medical Journal, Vol 128, Iss 24, Pp 3357-3362 (2015)
Druh dokumentu: article
ISSN: 0366-6999
DOI: 10.4103/0366-6999.171453
Popis: Background: Endothelial cell damage is an important pathophysiological step of restenosis after angioplasty and stenting. Cell transplantation has great therapeutic potential for endothelial recovery. We investigated the effect of transplanting endothelial progenitor cells (EPCs) derived from human early fetal aortas in rat injured arteries. Methods: The carotid arterial endothelium of Sprague-Dawley rats was damaged by dilatation with a 1.5 F balloon catheter, and then EPCs derived from human early fetal aortas (
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