| Autor: |
Chuanyou Xia, Thale Kristin Olsen, A. Ali Zirakzadeh, Radwa Almamoun, Louise K. Sjöholm, Jenny Dahlström, Jan Sjöberg, Hans-Erik Claesson, John Inge Johnsen, Ola Winqvist, Dawei Xu, Tomas J. Ekström, Magnus Björkholm, Klas Strååt |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 10 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2020.598872 |
| Popis: |
We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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