Hypertension and cystatin C account for sex differences in serum homocysteine levels in acute coronary syndrome subjects with normal serum creatinine

Autor:	Kun Shang, Xiang Ning, Jiangying Kuang, Aiying Xue, Xiao Yan, Huiqiang Chen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Sex difference Acute coronary syndrome Homocysteine Cystatin C Hypertension Creatinine Nutritional diseases. Deficiency diseases RC620-627 Public aspects of medicine RA1-1270
Zdroj:	Journal of Health, Population and Nutrition, Vol 42, Iss 1, Pp 1-7 (2023)
Druh dokumentu:	article
ISSN:	2072-1315
DOI:	10.1186/s41043-023-00430-1
Popis:	Abstract Background Hyperhomocysteinemia is one of cardiovascular disease risk factors and fasting homocysteine levels are significantly elevated in male compared to female acute coronary syndrome (ACS) patients with normal renal function. However, it is not known the sex related determinants of plasma homocysteine levels in ACS subjects without renal dysfunction. Methods A total of 165 ACS participants with normal plasma creatinine who underwent coronary angiography were included in the present study. Clinical parameters, homocysteine, fasting glucose and lipid profile, hemoglobin, white blood cell, platelets, creatinine, cystatin C, blood urea nitrogen, uric acid (UA), and albumin were measured. Multivariate linear regression analyses were used to recognize the predictive factors for homocysteine. Results The levels of plasma homocysteine were significantly higher in men than in women (P
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