Investigating the Anti-epileptic and Sedative Effects of Hydroalcoholic Extract of Melissa officinalis (Lemon Balm) Leaf on Pentylenetetrazol Induced Epileptiform Seizures in Wistar Rat
| Autor: | MB Ghayour, M Behnam-Rassouli, N Ghayour, M Tehranipour, A Kamyabi-Abkooh |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Medicinal Plants, Vol 11, Iss 41, Pp 64-73 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2717-204X 2717-2058 |
| Popis: | Background: Since long lasting administration of anti-seizure drugs produces undesirable side effects, many efforts have been made during recent decades to find and replace the chemical drugs by medicinal plants. Objective: The aim of present study was to study the antiepileptic (anti-seizure) effects of hydroalcoholic extract of Melissa officinalis on experimental epileptiform seizures, induced by pentylenetetrazol (PTZ) in Wistar rat. Methods: After normalization, rats in experimental groups 1, 2 and 3 were injected (i.p) 50, 80 and 120 mg/kg hydroalcoholic extract of Melissa officinalis , respectively. Control animals were injected extract solvent as the same manner. After 30 minutes all rats were injected (i.p) 80 mg/kg PTZ and then examined for epileptiform behaviors for the next 60 minutes. The rate of mortality during the next 24 hour was also recorded. Results: In comparison with control group, in all experimental groups the latent period of tonic-clonic generalized seizure was significantly (P |
| Databáze: | Directory of Open Access Journals |
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