Antimutagenic effect of curcumin and its effect on the immune response in mice
| Autor: | Petr Šmerák, Zdeňka Polívková, Helena Šestáková, Rudolf Štětina, Ivo Bárta, Martina Langová, Bohumil Turek, Jiřina Bártová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Czech Journal of Food Sciences, Vol 24, Iss 2, Pp 72-83 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1212-1800 1805-9317 |
| DOI: | 10.17221/3302-CJFS |
| Popis: | A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|