Development and validation of an automated Tomotherapy planning method for cervical cancer

Autor: Feiru Han, Yi Xue, Sheng Huang, Tong Lu, Yining Yang, Yuanjie Cao, Jie Chen, Hailing Hou, Yao Sun, Wei Wang, Zhiyong Yuan, Zhen Tao, Shengpeng Jiang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1748-717X
DOI: 10.1186/s13014-024-02482-x
Popis: Abstract Purpose This study aimed to develop an automated Tomotherapy (TOMO) planning method for cervical cancer treatment, and to validate its feasibility and effectiveness. Materials and methods The study enrolled 30 cervical cancer patients treated with TOMO at our center. Utilizing scripting and Python environment within the RayStation (RaySearch Labs, Sweden) treatment planning system (TPS), we developed automated planning methods for TOMO and volumetric modulated arc therapy (VMAT) techniques. The clinical manual TOMO (M-TOMO) plans for the 30 patients were re-optimized using automated planning scripts for both TOMO and VMAT, creating automated TOMO (A-TOMO) and automated VMAT (A-VMAT) plans. We compared A-TOMO with M-TOMO and A-VMAT plans. The primary evaluated relevant dosimetric parameters and treatment plan efficiency were assessed using the two-sided Wilcoxon signed-rank test for statistical analysis, with a P-value
Databáze: Directory of Open Access Journals
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