Bronchoscopic instillation of tranexamic acid to control bronchopulmonary bleeding

Autor: Emad El-Din A. Korraa, Ashraf M. Madkour, Iman H. Galal, Ibrahim M. Ibrahim El-Saidy
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: The Egyptian Journal of Bronchology, Vol 11, Iss 3, Pp 244-249 (2017)
Druh dokumentu: article
ISSN: 1687-8426
2314-8551
DOI: 10.4103/ejb.ejb_27_17
Popis: Abstract Background Tranexamic acid (TA), a potent antifibrinolytic agent, has the potency to stop bleeding in a variety of medical and surgical conditions. However, its role in controlling airway bleeding is not yet proven. This study aimed to evaluate the efficacy of endobronchial administration of TA in controlling bronchopulmonary bleeding. Materials and methods A prospective, comparative, observational study was carried out including 40 patients scheduled to undergo bronchoscopy. For management of hemoptysis or bronchoscopy-induced bleeding, patients were randomly subdivided into two groups of 20 patients each: the first group received endobronchial TA, whereas the second group received endobronchial cold saline±adrenaline. Results In the TA group, 19 patients were responders and only one patient was a nonresponder and was further managed with endobronchial adrenaline. All 20 patients of the cold saline±adrenaline group were responders. No significant statistical difference was found between both groups with regard to systolic and diastolic blood pressures, heart rate, and oxygen saturation either before or after bronchoscopy. However, heart rate significantly increased after bronchoscopy both in the first (P
Databáze: Directory of Open Access Journals
Externí odkaz: