THE RELATIONSHIP OF SERUM LEPTIN AND PLASMA APELIN LEVELS IN MEN WITH METABOLIC SYNDROME
| Autor: | A. V. Fedotova, E. N. Chernysheva, T. N. Panova, K. V. Akhtyamova |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Alʹmanah Kliničeskoj Mediciny, Vol 44, Iss 4, Pp 457-461 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2072-0505 2587-9294 |
| DOI: | 10.18786/2072-0505-2016-44-4-457-461 |
| Popis: | Background: The metabolic syndrome is seen as a cluster of high cardiovascular risk factors. New hormone-like substances, such as adipokines leptin and apelin, produced by fat tissue, are important for the pathophysiology of the metabolic syndrome.Aim: To evaluate levels of plasma apelin and serum leptin in patients with metabolic syndrome.Materials and methods: We examined 122 male patients with metabolic syndrome and 30 healthy males aged from 25 to 60 years. All patients were assessed accordingly to confirm the diagnosis of the metabolic syndrome, with additional measurements of serum leptin and plasma apelin.Results: Serum leptin levels were 10-fold higher and plasma apelin levels 3-fold higher in patients with metabolic syndrome (n=122), compared to the controls (n=30): 25.43 vs. 3.99 ng/mL (p0.05).Conclusion: The adipokine levels in men with metabolic syndrome are higher than in normal men. Serum leptin level is a sensitive parameter indicating accumulation of the fat tissue, irrespective of its localization. Plasma apelin is less sensitive, but it does reflect fat accumulation of the central (abdominal) type. |
| Databáze: | Directory of Open Access Journals |
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